CTH-Net: A CNN and Transformer hybrid network for skin lesion segmentation.

Automatically and accurately segmenting skin lesions can be challenging, due to factors such as low contrast and fuzzy boundaries. This paper proposes a hybrid encoder-decoder model (CTH-Net) based on convolutional neural network (CNN) and Transformer, capitalizing on the advantages of these approaches. We propose three modules for skin lesion segmentation and seamlessly connect them with carefully designed model architecture. Better segmentation performance is achieved by introducing SoftPool in the CNN branch and sandglass block in the bottleneck layer. Extensive experiments were conducted on four publicly accessible skin lesion datasets, ISIC 2016, ISIC 2017, ISIC 2018, and PH2 to confirm the efficacy and benefits of the proposed strategy. Experimental results show that the proposed CTH-Net provides better skin lesion segmentation performance in both quantitative and qualitative testing when compared with state-of-the-art approaches. We believe the CTH-Net design is inspiring and can be extended to other applications/frameworks.

Placental MRI segmentation based on multi-receptive field and mixed attention separation mechanism.

OBJECTIVE: To reduce the occurrence of massive bleeding during placental abruption in patients with placenta accrete, we established a medical imaging based on multi-receptive field and mixed attention separation mechanism (MRF-MAS) model to improve the accuracy of MRI placenta segmentation and provide a basis for subsequent placenta accreta. METHODS: We propose a placenta MRI segmentation technology using the MRF-MAS framework to develop a medical image diagnostic technique. The model first uses the multi-receptive field feature structure to obtain multi-level information, and improves the expression of features at differing scales. Note that the hybrid attention mechanism combines channel attention and spatial attention, separates the input feature sets and computes the attention separately, and finally reorganizes the feature maps. To show that the model can improve the accuracy of segmenting the placenta, we adopt mean Intersection over Union (IoU), Dice similarity coefficient (Dice) and area under the receiver operating characteristic curve (AUC) with U-Net, Mask RCNN, Deeplab v3 for comparison. RESULTS: The four models achieved different outcomes based on our placenta dataset, with our model IoU and Dice up to 0.8169 and 0.8992, which are 5.51% and 3.03% higher than the average of the three comparison models. CONCLUSION: The model proposed by us is helpful to assist the imaging diagnosis and at the same time provides a quantitative reference for the precise treatment of placenta accreta, assists the Equationtion of the clinical operation plan of the physician, and promotes the precision medicine of placenta accreta.

HViT: Hybrid vision inspired transformer for the assessment of carotid artery plaque by addressing the cross-modality domain adaptation problem in MRI.

BACKGROUND: Medical image classification is crucial for accurate and efficient diagnosis, and deep learning frameworks have shown significant potential in this area. When a general learning deep model is directly deployed to a new dataset with heterogeneous features, the effect of domain shifts is usually ignored, which degrades the performance of deep learning models and leads to inaccurate predictions. PURPOSE: This study aims to propose a framework that utilized the cross-modality domain adaptation and accurately diagnose and classify MRI scans and domain knowledge into stable and vulnerable plaque categories by a modified Vision Transformer (ViT) model for the classification of MRI scans and transformer model for domain knowledge classification. METHODS: This study proposes a Hybrid Vision Inspired Transformer (HViT) framework that employs a convolutional layer for image pre-processing and normalization and a 3D convolutional layer to enable ViT to classify 3D images. Our proposed HViT framework introduces a slim design with a multi-branch network and channel attention, improving patch embedding extraction and information learning. Auxiliary losses target shallow features, linking them with deeper ones, enhancing information gain, and model generalization. Furthermore, replacing the MLP Head with RNN enables better backpropagation for improved performance. Moreover, we utilized a modified transformer model with LSTM positional encoding and Golve word vector to classify domain knowledge. By using ensemble learning techniques, specifically stacking ensemble learning with hard and soft prediction, we combine the predictive power of both models to address the cross-modality domain adaptation problem and improve overall performance. RESULTS: The proposed framework achieved an accuracy of 94.32% for carotid artery plaque classification into stable and vulnerable plaque by addressing the cross-modality domain adaptation problem and improving overall performance. CONCLUSION: The model was further evaluated using an independent dataset acquired from different hardware protocols. The results demonstrate that the proposed deep learning model significantly improves the generalization ability across different MRI scans acquired from different hardware protocols without requiring additional calibration data.

End to end vision transformer architecture for brain stroke assessment based on multi-slice classification and localization using computed tomography.

BACKGROUND: Brain stroke is a leading cause of disability and death worldwide, and early diagnosis and treatment are critical to improving patient outcomes. Current stroke diagnosis methods are subjective and prone to errors, as radiologists rely on manual selection of the most important CT slice. This highlights the need for more accurate and reliable automated brain stroke diagnosis and localization methods to improve patient outcomes. PURPOSE: In this study, we aimed to enhance the vision transformer architecture for the multi-slice classification of CT scans of each patient into three categories, including Normal, Infarction, Hemorrhage, and patient-wise stroke localization, based on end-to-end vision transformer architecture. This framework can provide an automated, objective, and consistent approach to stroke diagnosis and localization, enabling personalized treatment plans based on the location and extent of the stroke. METHODS: We modified the Vision Transformer (ViT) in combination with neural network layers for the multi-slice classification of brain CT scans of each patient into normal, infarction, and hemorrhage classes. For stroke localization, we used the ViT architecture and convolutional neural network layers to detect stroke and localize it by bounding boxes for infarction and hemorrhage regions in a patient-wise manner based on multi slices. RESULTS: Our proposed framework achieved an overall accuracy of 87.51% in classifying brain CT scan slices and showed high precision in localizing the stroke patient-wise. Our results demonstrate the potential of our method for accurate and reliable stroke diagnosis and localization. CONCLUSION: Our study enhanced ViT architecture for automated stroke diagnosis and localization using brain CT scans, which could have significant implications for stroke management and treatment. The use of deep learning algorithms can provide a more objective and consistent approach to stroke diagnosis and potentially enable personalized treatment plans based on the location and extent of the stroke. Further studies are needed to validate our method on larger and more diverse datasets and to explore its clinical utility in real-world settings.

STG-Net: A COVID-19 prediction network based on multivariate spatio-temporal information.

The modern urban population features a high population density and a fast population flow, and COVID-19 has strong transmission ability, long incubation period, and other characteristics. Considering only the time sequence of COVID-19 transmission cannot effectively respond to the current epidemic transmission situation. The distance between cities and population density information also have a significant impact on the transmission of the virus. Currently, cross-domain transmission prediction models do not fully exploit the time-space information and fluctuation trend of data, and cannot reasonably predict the trend of infectious diseases by integrating time-space multi-source information. To solve this problem, this paper proposes the COVID-19 prediction network (STG-Net) based on multivariate spatio-temporal information, which introduces the Spatial Information Mining module (SIM) and the Temporal Information Mining module (TIM) to mine the spatio-temporal information of the data in a deeper level, and uses the slope feature method to further mine the fluctuation trend of the data. Also, we introduce the Gramian Angular Field module (GAF), which converts one-dimensional data into two-dimensional images, further enhancing the network's feature mining capability in the time and feature dimension, ultimately combining spatiotemporal information to predict daily newly confirmed cases. We tested the network on datasets from China, Australia, the United Kingdom, France, and Netherlands. The experimental results show that STG-Net has better prediction performance than existing prediction models, with an average decision coefficient R2 of 98.23% on the datasets from five countries, as well as good long- and short-term prediction ability and overall good robustness.

Unsupervised domain adaptive myocardial infarction MRI classification diagnostics model based on target domain confused sample resampling.

OBJECTIVE: Inefficient circulatory system due to blockage of blood vessels leads to myocardial infarction and acute blockage. Myocardial infarction is frequently classified and diagnosed in medical treatment using MRI, yet this method is ineffective and prone to error. As a result, there are several implementation scenarios and clinical significance for employing deep learning to develop computer-aided algorithms to aid cardiologists in the routine examination of cardiac MRI. METHODS: This research uses two distinct domain classifiers to address this issue and achieve domain adaptation between the particular field and the specific part is a problem Current research on environment adaptive systems cannot effectively obtain and apply classification information for unsupervised scenes of target domain images. Insufficient information interchange between specific domains and specific domains is a problem. In this study, two different domain classifiers are used to solve this problem and achieve domain adaption. To effectively mine the source domain images for classification understanding, an unsupervised MRI classification technique for myocardial infarction called CardiacCN is proposed, which relies on adversarial instructions related to the interpolation of confusion specimens in the target domain for the conflict of confusion specimens for the target domain classification task. RESULTS: The experimental results demonstrate that the CardiacCN model in this study performs better on the six domain adaption tasks of the Sunnybrook Cardiac Dataset (SCD) dataset and increases the mean target area myocardial infarction MRI classification accuracy by approximately 1.2 percent. The classification performance of the CardiacCN model on the target domain does not vary noticeably when the temperature-controlled duration hyper-parameter rl falls in the region of 5-30. According to the experimental findings, the CardiacCN model is more resistant to the excitable rl. The CardiacCN model suggested in this research may successfully increase the accuracy of the source domain predictor for the target domain myocardial infarction clinical scanning classification in unsupervised learning, as shown by the visualization analysis infrastructure provision nurture. It is evident from the visualization assessment of embedded features that the CardiacCN model may significantly increase the source domain classifier's accuracy for the target domain's classification of myocardial infarction in clinical scans under unsupervised conditions. CONCLUSION: To address misleading specimens with the inconsistent classification of target-domain myocardial infarction medical scans, this paper introduces the CardiacCN unsupervised domain adaptive MRI classification model, which relies on adversarial learning associated with resampling target-domain confusion samples. With this technique, implicit image classification information from the target domain is fully utilized, knowledge transfer from the target domain to the specific domain is encouraged, and the classification effect of the myocardial ischemia medical scan is improved in the target domain of the unsupervised scene.

DE-MRI myocardial fibrosis segmentation and classification model based on multi-scale self-supervision and transformer.

OBJECTIVE: The segmentation and categorization of fibrotic tissue in time-lapse enhanced MRI scanning are quite challenging, and it is mainly done manually for myocardial DE-MRI images. On the other hand, DE-MRI instructions for segmenting and classifying cardiac hypertrophy are complex and prone to inaccuracy. Developing cardiac DE-MRI classification and prediction methods is crucial. METHODS: This paper introduces a self-supervised myocardial histology segmentation algorithm with multi-scale portrayal consistency to address the degree of sophistication of cardiology DE-MRI. The model retrieves multi-scale representations from multiple expanded viewpoints using a Siamese system and uses resemblance learning instruction to achieve unlabeled representations. The DE-MRI data train the network weights to generate a superior segmentation effect by accurately reflecting the exact scale information. The paper provides an end-to-end method for detecting myocardial fibrosis tissue using a Transformer as a result of the poor classification outcomes of myocardial fibrosis substance in DE-MRI. A deep learning model is created using the Pre-LN Transformer decoded simultaneously with the Multi-Scale Transformer backbone structure developed in this paper. In addition, the joint regression cost, which incorporates the CIoU Loss and the L1 Loss, is used to determine the distance between forecast blocks and labels. RESULTS: Increasing the independent evaluation and annotations position compared enhances performance compared to the segmentation method without canvas matching by 1.76%, 1.27%, 0.93%, and -1.17 mm on Dice, PPV, SEN, and HD, respectively. Based on the strongest of the three single-scale representation methodologies, the segmentation model in this study is enhanced by 0.71%, 0.79%, and 1.47%, as well as -1.49 mm on Dice, PPV, SEN, and HD, respectively. The effectiveness and reliability of the segmentation model are confirmed. Additionally, testing results show that this study's recognition system's mAP is 84.97%, which is greater than the benchmark techniques used in most other studies. The framework converges round is compressed by 18.1% compared to the DETR detection approach, and the identification rate is improved by 3.5%, proving the strategy's value. CONCLUSION: The self-supervised cardiac fibrosis segmentation method with multi-scale portrayal consistency and end-to-end myocardial histology categorization is introduced in this study. To solve the challenges of segmentation and myocardial fibrosis identification in cardiology DE-MRI, a Transformer-based detection approach is put forth. It may address the issue of the myocardial scarring material's low accuracy in segmentation and classification in DE-MRI, as well as provide clinicians with a fibrosis diagnosis that is supplementary to the conventional therapy of heart ailments.

Classification of myocardial fibrosis in DE-MRI based on semi-supervised semantic segmentation and dual attention mechanism.

OBJECTIVE: It is essential to utilize cardiac delayed-enhanced magnetic resonance imaging (DE-MRI) to diagnose cardiovascular disease. By segmenting myocardium DE-MRI images, it provides critical information for the evaluation and treatment of myocardial infarction. As a consequence, it is vital to investigate the segmentation and classification technique of myocardial DE-MRI. METHODS: Firstly, an end-to-end minimally supervised and semi-supervised semantic DE-MRI myocardial fibrosis segmentation framework is proposed, which combines image classification and semantic segmentation branches based on the self-attention mechanism. Following that, a residual hole network fused with the dual attention mechanism was built, and a double attention metabolic pathway classification method for cardiac fibrosis in DE-MRI images was developed. RESULTS: By adding pixel-level labels to an extra 40 training images, the segmentation model may enhance semantic segmentation performance by 2.6 percent (from 61.2 percent to 63.8 percent). When the number of pixel-level labels is increased to 80, semi-supervised feature extraction increases by 4.7 percent when compared to weakly guided semantic segmentation. Adding an attention mechanism to the critical network DRN (Deep Residual Network) can increase the classifier's performance by a small amount. Experiments revealed that the models worked effectively. CONCLUSION: This paper investigates the segmentation and classification of cardiac fibrosis in DE-MRI data using a semi-supervised semantic segmentation and dual attention mechanism, dealing with the issue that existing segmentation algorithms have difficulty segmenting myocardial fibrosis tissue. In the future, we can consider optimizing the design of the attention module to reduce the module computation.

VOC-DL: Deep learning prediction model for COVID-19 based on VOC virus variants.

BACKGROUND AND OBJECTIVE: The ever-mutating COVID-19 has infected billions of people worldwide and seriously affected the stability of human society and the world economic development. Therefore, it is essential to make long-term and short-term forecasts for COVID-19. However, the pandemic situation in different countries and regions may be dominated by different virus variants, and the transmission capacity of different virus variants diversifies. Therefore, there is a need to develop a predictive model that can incorporate mutational information to make reasonable predictions about the current pandemic situation. METHODS: This paper proposes a deep learning prediction framework, VOC-DL, based on Variants Of Concern (VOC). The framework uses slope feature method to process the time series dataset containing VOC variant information, and uses VOC-LSTM, VOC-GRU and VOC-BILSTM prediction models included in the framework to predict the daily newly confirmed cases. RESULTS: We analyzed daily newly confirmed cases in Italy, South Korea, Russia, Japan and India from April 14th, 2021 to July 3rd, 2021. The experimental results show that all VOC-DL models proposed in this paper can accurately predict the pandemic trend in the medium and long term, and VOC-LSTM model has the best prediction performance, with the highest average determination coefficient R2 of 96.83% in five nations' datasets. The overall prediction has robustness. CONCLUSIONS: The experimental results show that VOC-LSTM is the best predictor for such a series of data and has higher prediction accuracy in the long run. At the same time, our VOC-DL framework combining VOC variants has reference significance for predicting other variants in the future.

Ribophorin II promotes the epithelial-mesenchymal transition and aerobic glycolysis of laryngeal squamous cell carcinoma via regulating reactive oxygen species-mediated Phosphatidylinositol-3-Kinase/Protein Kinase B activation.

Ribophorin II (RPN2), a part of an N-oligosaccharyl transferase complex, plays vital roles in the development of multiple cancers. Nevertheless, its biological role in laryngeal squamous cell carcinoma (LSCC) remains unclear. The RPN2 expression levels in LSCC tissues and cell lines (AMC-HN-8 and TU212) were measured using real-time PCR, immunohistochemistry, or Western blot. The influences of RPN2 on the proliferation, migration, epithelial-mesenchymal transition, and aerobic glycolysis of LSCC cells were investigated after upregulation or downregulation of RPN2 in vitro and in vivo. Mechanically, we assessed the impact of RPN2 on the reactive oxygen species (ROS)/Phosphatidylinositol-3-Kinase (PI3K)/Protein Kinase B (Akt) signaling pathway. We found that compared with the control, RPN2 was highly expressed in LSCC tissues and cells. Overexpression of RPN2 elevated the proliferation, migration, glucose uptake, lactate production release, and levels of Vimentin, hexokinase-2 (HK-2), pyruvate dehydrogenase kinase 1 (PDK1), lactate dehydrogenase A (LDHA), and ROS, but inhibited E-cadherin expression in AMC-HN-8 cells. Knockdown of RPN2 in TU212 cells showed opposite effects on the above indexes. Meanwhile, RPN2 upregulation increased the levels of p-PI3K/PI3K and p-Akt/Akt, which were attenuated by N-acetyl-L-cysteine (NAC), an ROS inhibitor. Both NAC and PI3K inhibitor LY294002 could reverse the effects of RPN2 overexpression on the malignant phenotypes of LSCC cells. In xenografted mice, silencing RPN2 expression reduced tumor growth, ROS production, and levels of Ki-67, Vimentin, LDHA, and p-Akt/Akt, but enhanced E-cadherin expression. In conclusion, our data suggested that RPN2 promoted the proliferation, migration, EMT, and glycolysis of LSCC via modulating ROS-mediated PI3K/Akt activation.

SIRVD-DL: A COVID-19 deep learning prediction model based on time-dependent SIRVD.

COVID-19 is one of the biggest challenges that human beings have faced recently. Many researchers have proposed different prediction methods for establishing a virus transmission model and predicting the trend of COVID-19. Among them, the methods based on artificial intelligence are currently the most interesting and widely used. However, only using artificial intelligence methods for prediction cannot capture the time change pattern of the transmission of infectious diseases. To solve this problem, this paper proposes a COVID-19 prediction model based on time-dependent SIRVD by using deep learning. This model combines deep learning technology with the mathematical model of infectious diseases, and forecasts the parameters in the mathematical model of infectious diseases by fusing deep learning models such as LSTM and other time prediction methods. In the current situation of mass vaccination, we analyzed COVID-19 data from January 15, 2021, to May 27, 2021 in seven countries - India, Argentina, Brazil, South Korea, Russia, the United Kingdom, France, Germany, and Italy. The experimental results show that the prediction model not only has a 50% improvement in single-day predictions compared to pure deep learning methods, but also can be adapted to short- and medium-term predictions, which makes the overall prediction more interpretable and robust.

A Novel Method to Rank Influential Nodes in Complex Networks Based on Tsallis Entropy.

With the rapid development of social networks, it has become extremely important to evaluate the propagation capabilities of the nodes in a network. Related research has wide applications, such as in network monitoring and rumor control. However, the current research on the propagation ability of network nodes is mostly based on the analysis of the degree of nodes. The method is simple, but the effectiveness needs to be improved. Based on this problem, this paper proposes a method that is based on Tsallis entropy to detect the propagation ability of network nodes. This method comprehensively considers the relationship between a node's Tsallis entropy and its neighbors, employs the Tsallis entropy method to construct the TsallisRank algorithm, and uses the SIR (Susceptible, Infectious, Recovered) model for verifying the correctness of the algorithm. The experimental results show that, in a real network, this method can effectively and accurately evaluate the propagation ability of network nodes.

TW-SIR: time-window based SIR for COVID-19 forecasts.

Since the outbreak of COVID-19, many COVID-19 research studies have proposed different models for predicting the trend of COVID-19. Among them, the prediction model based on mathematical epidemiology (SIR) is the most widely used, but most of these models are adapted in special situations based on various assumptions. In this study, a general adapted time-window based SIR prediction model is proposed, which is characterized by introducing a time window mechanism for dynamic data analysis and using machine learning method predicts the basic reproduction number and the exponential growth rate of the epidemic. We analyzed COVID-19 data from February to July 2020 in seven countries---China, South Korea, Italy, Spain, Brazil, Germany and France, and the numerical results showed that the framework can effectively measure the real-time changes of the parameters during the epidemic, and error rate of predicting the number of COVID-19 infections in a single day is within 5%.